منابع مشابه
Ultrastructure of Na,K-transport vesicles reconstituted with purified renal Na,K-ATPase
To study the size and structure of the Na,K-pump molecule, the ultrastructure of phospholipid vesicles was examined after incorporation of purified Na,K-ATPase which catalyzes active coupled transport of Na+ and K+ in a ratio close to 3Na/2K. The vesicles were analyzed by thin sectioning and freeze-fracture electron microscopy after reconstitution with different ratios of Na,K-ATPase protein to...
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1 A specific and essential role for Na,K-ATPase α3 in neurons co-expressing α1 and α3* Background: Neurons express two Na,K-ATPase isoforms, the ubiquitous α1 and neuron-specific α3. Result: α3 is important for control of membrane potential and is fully responsible for restoration of large [Na + ] i increases. Conclusion: α1 and α3 are required for basal neuronal function, but α3 controls resto...
متن کاملMolecular activity of Na+/K+-ATPase
species in a predictable manner. For example, it is several-fold greater in endothermic than in ectothermic vertebrate species when measured at the same body temperature. This difference in metabolic activity appears to be primarily a cellular phenomenon, and it has recently been proposed that it is related to differences in membrane composition (Hulbert and Else, 1999, 2000). A substantial pro...
متن کاملTranscriptional regulators of Na,K-ATPase subunits
The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalyti...
متن کاملH2O2-modification of Na,K-ATPase. Alterations in external Na+ and K+ stimulation of K+ influx.
Studies, at steady state, of the Na,K-ATPase dependent influx of K+ into bovine lenses in organ culture are used to characterize further the H2O2-modification of the Na+ pump. Control lenses display constants for interaction with external Na+ and K+ similar to those obtained for the erythrocyte. H2O2 treatment of the bovine lens leads to total loss of external Na+ stimulation and alteration of ...
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ژورنال
عنوان ژورنال: ACTA HISTOCHEMICA ET CYTOCHEMICA
سال: 1980
ISSN: 0044-5991,1347-5800
DOI: 10.1267/ahc.13.103